Parkinson’s disease
|
Degenerative disorder of
CNS associated with Lewis bodies and depigmentation of the substantia nigra
pars compacta.
Tremor at rest,
pill-rolling tremor, cogwheel rigidity, akinesia, and postural instability.
|
Hemibalismus
|
Sudden, wild flailing of
one arm (sometime one leg).
Characterized by
Subthalamic nucleus lesion.
Loss of inhibition of
thalamus through globus pallidus.
|
Huntington’s disease
|
Autosomal dominant trinucleotide
(CAG) repeats disorder.
Chorea, aggression, depression,
and dementia.
Atrophy of striatal nuclei
(main inhibitor of movement). Caudate loses ACh and GABA.
|
Chorea
|
Sudden, jerky, purposeless
movement.
Basal ganglia lesion e.g.
Huntington’s disease.
|
Athetosis
|
Slow, writing movements,
especially of fingers.
Basal ganglia lesion.
|
Myoclonus
|
Sudden, brief muscle
contraction.
Jerks, hiccups.
|
Dystonia
|
Sustained, involuntary
muscle contractions.
Writer’s cramps.
|
[1] (Le, Bhushan, & Grimm, 2009)
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