Wednesday, September 19, 2012

CNS DISORDERS [1]: BRIEF REVIEW.

Parkinson’s disease
Degenerative disorder of CNS associated with Lewis bodies and depigmentation of the substantia nigra pars compacta.
Tremor at rest, pill-rolling tremor, cogwheel rigidity, akinesia, and postural instability.
Hemibalismus
Sudden, wild flailing of one arm (sometime one leg).
Characterized by Subthalamic nucleus lesion.
Loss of inhibition of thalamus through globus pallidus.
Huntington’s disease
Autosomal dominant trinucleotide (CAG) repeats disorder.
Chorea, aggression, depression, and dementia.
Atrophy of striatal nuclei (main inhibitor of movement). Caudate loses ACh and GABA.
Chorea
Sudden, jerky, purposeless movement.
Basal ganglia lesion e.g. Huntington’s disease.
Athetosis
Slow, writing movements, especially of fingers.
Basal ganglia lesion.
Myoclonus
Sudden, brief muscle contraction.
Jerks, hiccups.
Dystonia
Sustained, involuntary muscle contractions.
Writer’s cramps.

[1]  (Le, Bhushan, & Grimm, 2009)

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