A hydatidiform mole is a noninvasive tumor caused by aberrant fertilization , leading to cystic swelling of chorionic villi and proliferation of the trophoblast. It result in a mass that can look like a “cluster of grapes”. Hydatidiform Mole can be complete or partial. The genotype of a complete moles is usually 46,XX, completely consisting of paternal DNA. It result when two sperm fertilize an empty egg. There is no associated fetus despite the eleveted levels of β-human chorionic gonadotropin.
The genotype 46,XX, maternal would not cause a hydatidiform mole. Mole are derived from empty ova that are then fertilized by sperm. 46,XX maternal and paternal describe a genotype of a normal fetus, receiving one set of chromosomes from each parent.
69, XXX; 69 XXY or 69 XYY, maternal and paternal describe another posible DNA make up of a partial mole. A partial mole contains more than two set of chromosomes thet usually consist of two paternal and one maternal, or consist of both paternal and maternal set, resulting in triploidy or tetraploidy. Partial moles may present with a similar grape like mass and are associated with fetal parts.
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